Peter Bayguinov, Ph.D.

Two-photon and Super-resolution Microscopy
Research Specialist, WUCCI

Dr. Bayguinov joined the WUCCI in October of 2017. His primary role is to assist and train users of the Center in the use of advanced imaging techniques, the development of strategies for specific live cell and dynamic imaging experiments, and the incorporation and application of novel imaging modalities within the Center.

Dr. Bayguinov has over 13 years of experience in using diverse imaging approaches to study various biological systems. He did his doctoral work at the University of Nevada with Dr. Terence Smith, where he studied the integration of the enteric nervous system during specific motor behaviors using dynamic Ca2+ imaging in conjunction with post-hoc immunohistochemical analyses. Peter also spent 6 years at the University of Wisconsin- Madison, where he was a postdoctoral fellow in the lab of Dr. Meyer Jackson. During his tenure there, he used electrophysiological and voltage imaging approaches to explore circuit-level neuronal interactions in superior colliculus, hippocampus, and cerebral cortex. He was also involved in the generation and application of a genetically-encoded voltage sensor expressed in specific subpopulations of neurons, a work which was featured on the cover of the Journal of Neuroscience in September 2017. Peter also has extensive experience with multiphoton microscopy, TIRF microscopy, as well as superresolution imaging approaches.


  • B.S. in Biology (Cell and Molecular), University of Washington, Seattle, WA, USA
  • Ph.D. in Cellular and Molecular Pharmacology and Physiology, University of Nevada, Reno, NV, USA
  • Postdoctoral Researcher, University of Wisconsin, Madison, WI, USA

Selected Publications

  • Bayguinov PO, Ma Y, Gao Y, Zhao X, Jackson MB (2017). Imaging Voltage in Genetically-Defined Neuronal Populations with a Cre-lox Targeted Hybrid Voltage Sensor. J Neuroscience. 2017 Sep 20;37(38):9305-9319.
  • Ma Y, Bayguinov PO, Jackson MB (2017). Action potential dynamics in fine axons probed with an axonally-targeted hybrid genetically-encoded optical voltage sensor. eNeuro. 2017 Jul 25;4(4).
  • Bayguinov PO, Ghitani N, Jackson MB & Basso MA (2015). A Hard-Wired Priority Map in the Superior Colliculus Shaped by Asymmetric Inhibitory Circuitry. J Neurophysiol 2015 Jul;114(1):662-76.
  • Ghitani N, Bayguinov PO, Ma Y, Jackson MB (2015). Single-trial imaging of spikes and synaptic potentials in single neurons in brain slices with genetically encoded hybrid voltage sensor. J Neurophysiol. Feb 15;113(4):1249-59.
  • Ghitani N, Bayguinov PO, Vokoun CR, McMahon S, Jackson MB & Basso MA (2014). Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus. J. Neuroscience. May 14;34(20):6822-33.
  • Bayguinov PO, Broadhead MJ, Okamoto T, Hennig GW & Smith TK (2012). Activity in varicosities within the myenteric plexus between and during the colonic migrating motor complex in the isolated murine large intestine. Neurogastroenterol Motil Apr;24(4):e185-201.
  • Broadhead MJ, Bayguinov PO*, Okamoto T, Heredia DJ & Smith TK (2012). Ca2+ transients in myenteric glial cells during the colonic migrating motor complex in the isolated murine large intestine. J Physiol 590, 335-350.
  • Bayguinov PO, Hennig GW & Smith TK. (2010). Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine. J Physiol 588.22 4453–4474.
  • Bayguinov PO, Hennig GW & Smith TK. (2010). Generation of complex neuronal behavior in a mammalian nervous system. Physiology News Autumn, 80.
  • Heredia DJ, Dickson EJ, Bayguinov PO*, Hennig GW & Smith TK. (2010). Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel. J Physiol 588, 2919-2934.
  • Bayguinov PO, Hennig GW & Smith TK. (2010). Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon. J Physiol 588, 399-421.
  • Lee HT, Hennig GW, Park KJ, Bayguinov PO, Ward SM, Sanders KM & Smith TK. (2009). Heterogeneities in ICC Ca2+ activity within canine large intestine. Gastroenterology 136, 2226-2236.
  • Heredia DJ, Dickson EJ, Bayguinov PO, Hennig GW & Smith TK. (2009). Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon. Gastroenterology 136, 1328-1338.
  • Dickson EJ, Spencer NJ, Hennig GW, Bayguinov PO, Ren J, Heredia DJ & Smith TK. (2007). An enteric occult reflex underlies accommodation and slow transit in the distal large bowel. Gastroenterology 132, 1912-1924.
  • Spencer NJ, Bayguinov PO*, Hennig GW, Park KJ, Lee HT, Sanders KM & Smith TK. (2007). Activation of neural circuitry and Ca2+ waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice. Am J Physiol 292, G546-555.