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WashU Hosts Cryo-EM Symposium

WashU Hosts Cryo-EM Symposium

December 7, 2023 | 1:00pm – 4:00pm Join us at Washington University in St. Louis to learn about the adoption of Cryo Electron Microscopy (cryo- EM) as a versatile, multidisciplinary approach to analyze protein structure. Using cryo-EM, scientists can directly image and analyze structural details in 3D, enabling them to characterize mechanisms of action, discover […]
Fitzpatrick Awarded NIMH S10 Instrument Grant

Fitzpatrick Awarded NIMH S10 Instrument Grant

Six investigators from the Departments of Genetics and Neuroscience at the School of Medicine will make use of this imaging platform to enable a wide-range of studies aimed at investigating the genetic regulation of synapse-localized translation, the molecular mechanisms of gene regulation as well as the discovery and characterization of genetic etiological factors involved in Autism Spectrum Disorder (ASD), how mGluR5 mediated signal transduction is implicated in anxiety and depression and how loss of hippocampal activity leads to learning and memory deficits in cognitive disease.
NCI Awards HTAN 3D Imaging Grant to Fitzpatrick and Collaborators

NCI Awards HTAN 3D Imaging Grant to Fitzpatrick and Collaborators

We propose a cross-disciplinary approach to quantitatively characterize the native three-dimensional architecture of human solid tumor tissue from triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) patients using a combination of the state-of-the art, yet mature technologies of tissue clearing, immunofluorescence and in situ hybridization labeling, and high-resolution lightsheet fluorescence microscopy.
NINDS Awards U01 for A-syn Cryo-EM

NINDS Awards U01 for A-syn Cryo-EM

In this project, we will use cryo-electron microscopy (cryo-EM) to determine atomic resolution structures of Asyn fibrils in Lewy body dementia, in conjunction with solid-state NMR (SSNMR) for refinement of structures.
Fitzpatrick Awarded NIH HEI S10 Grant

Fitzpatrick Awarded NIH HEI S10 Grant

This microscope system will allow innovative nanomanipulation of vitrified cells and tissues into thin lamellae (~300 nm thickness) for Cryo-Electron Tomography (Cryo-ET), and will facilitate the in situ elucidation of three-dimensional structures of cellular organelles and macromolecular complexes at nanometer resolution.