Fitzpatrick Awarded NIMH S10 Instrument Grant

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Six investigators from the Departments of Genetics and Neuroscience at the School of Medicine will make use of this imaging platform to enable a wide-range of studies aimed at investigating the genetic regulation of synapse-localized translation, the molecular mechanisms of gene regulation as well as the discovery and characterization of genetic etiological factors involved in Autism Spectrum Disorder (ASD), how mGluR5 mediated signal transduction is implicated in anxiety and depression and how loss of hippocampal activity leads to learning and memory deficits in cognitive disease.

NCI Awards HTAN 3D Imaging Grant to Fitzpatrick and Collaborators

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We propose a cross-disciplinary approach to quantitatively characterize the native three-dimensional architecture of human solid tumor tissue from triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) patients using a combination of the state-of-the art, yet mature technologies of tissue clearing, immunofluorescence and in situ hybridization labeling, and high-resolution lightsheet fluorescence microscopy.

NIDDK Awards Program Project Grant to Develop New Therapies for Liver Fibrosis

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This program project will discover and test novel compounds as potential therapeutic agents, as well as test and discover signaling pathways as potential modifiers, of liver disease due to α1antitrypsin deficiency (ATD), one of the most common genetic causes of liver disease and a frequent indication for liver transplantation.

NINDS Awards U01 for A-syn Cryo-EM

National Institute of Neurological Disorders and Stroke logo

In this project, we will use cryo-electron microscopy (cryo-EM) to determine atomic resolution structures of Asyn fibrils in Lewy body dementia, in conjunction with solid-state NMR (SSNMR) for refinement of structures.

Fitzpatrick Awarded NIH HEI S10 Grant

This microscope system will allow innovative nanomanipulation of vitrified cells and tissues into thin lamellae (~300 nm thickness) for Cryo-Electron Tomography (Cryo-ET), and will facilitate the in situ elucidation of three-dimensional structures of cellular organelles and macromolecular complexes at nanometer resolution.